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KCNMB1 (基因名), Calcium-activated potassium channel subunit beta-1 (蛋白名), kcmb1_canfa.

产品名称:

Dog KCNMB1/ Calcium-activated potassium channel subunit beta-1 CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

BK channel subunit beta-1, Calcium-activated potassium channel, subfamily M subunit beta-1, Charybdotoxin receptor subunit beta-1, K(VCA)beta-1, Maxi K channel subunit beta-1, Slo-beta-1, BKbeta, BKbeta1, Calcium-activated potassium channel subunit beta, Slo-beta

检测方法:

CLIA

特异性:

Natural and recombinant dog Calcium-activated potassium channel subunit beta-1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

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通用注释

亚单元:

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer.

功能:

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.

亚细胞位置:

Membrane Multi-pass membrane protein

数据库链接

Uniprot:

Q28266