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KCNMA1 (基因名), Calcium-activated potassium channel subunit alpha-1 (蛋白名), kcma1_bovin.

产品名称:

Bovine KCNMA1/ Calcium-activated potassium channel subunit alpha-1 CLIA Kit

货号:

U15712b

商标:

EIAab^®

监管等级:

RUO

别名:

BK channel, bSlo, BKCA alpha, Calcium-activated potassium channel, subfamily M subunit alpha-1, K(VCA)alpha, KCa1.1, Maxi K channel, Slo-alpha, Slo1, Slowpoke homolog, MaxiK, Slo homolog, KCNMA

检测方法:

CLIA

特异性:

Natural and recombinant bovine Calcium-activated potassium channel subunit alpha-1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Immunology

规格 & 价格:

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通用注释

亚单元:

Homotetramer; which constitutes the calcium-activated potassium channel. Interacts with beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4. Interacts with gamma subunits LRRC26, LRRC38, LRRC52 and LRRC55. Beta and gamma subunits are accessory, and modulate its activity. Interacts with RAB11B.

功能:

Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).

亚细胞位置:

Cell membrane Multi-pass membrane protein

数据库链接

UniGene:

Bt.106645

STRING:

9913.ENSBTAP00000047743

KEGG:

bta:282573

Pfam:

PF03493

Uniprot: