CAMK2B (基因名), Calcium/calmodulin-dependent protein kinase type II subunit beta (蛋白名), kcc2b_human.
产品名称:
Human CAMK2B/ Calcium/calmodulin-dependent protein kinase type II subunit beta CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
CaM kinase II subunit beta, CAM2, CAMK2, CAMKB
检测方法:
CLIA
特异性:
Natural and recombinant human Calcium/calmodulin-dependent protein kinase type II subunit beta
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (PubMed:14722083, Ref.19). Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ (PubMed:15312654). Interacts with FOXO3.
功能:
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
亚细胞位置:
Cytoplasm
Cytoskeleton
Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
Sarcoplasmic reticulum membrane
Peripheral membrane protein
Cytoplasmic side
In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.
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