Kalrn (基因名), Kalirin (蛋白名), kalrn_rat.
产品名称:
Rat Kalrn/ Kalirin CLIA Kit
Kalirin
货号:
U14464r
商标:
EIAab®
监管等级:
别名:
Huntingtin-associated protein-interacting protein, PAM COOH-terminal interactor protein 10, Protein Duo, Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, P-CIP10, Duo, Hapip
检测方法:
CLIA
特异性:
Natural and recombinant rat Kalirin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1). Interacts with FASLG.
功能:
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation.
亚细胞位置:
Cytoplasm
Cytoplasm
Cytoskeleton
Isoform 6 is largely associated with synaptosomal membranes and to punctate structures in cortical neurons. Isoforms 1 and 7 are expressed in neuronal cell bodies, isoform 7 is also found in neuronal processes.
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