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Itpr1 (基因名), Inositol 1,4,5-trisphosphate receptor type 1 (蛋白名), itpr1_rat.

产品名称:

Rat Itpr1/ Inositol 1,4,5-trisphosphate receptor type 1 CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

IP3 receptor isoform 1, Type 1 inositol 1, 4, 5-trisphosphate receptor, IP-3-R, Type 1 InsP3 receptor, Insp3r

检测方法:

CLIA

特异性:

Natural and recombinant rat Inositol 1,4,5-trisphosphate receptor type 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Neurosciences

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Rat Itpr1 CLIA Kit

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通用注释

亚单元:

omotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with MRVI1 and CABP1 (via N-terminus). Interacts with TESPA1. Interacts (when not phosphorylated) with AHCYL1 (when phosphorylated); the interaction suppresses inositol 1,4,5-trisphosphate binding to ITPR1. Interacts with AHCYL2 (with lower affinity than with AHCYL1) (By similarity). Interacts with BOK (via BH4 domain); protects ITPR1 from proteolysis by CASP3 during apoptosis.

功能:

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

亚细胞位置:

Endoplasmic reticulum membrane Multi-pass membrane protein Cytoplasmic vesicle Secretory vesicle membrane Multi-pass membrane protein Cytoplasm Perinuclear region Endoplasmic reticulum and secretory granules (By similarity).

数据库链接

UniGene:

Rn.2135

SMR:

P29994

STRING:

10116.ENSRNOP00000063885

KEGG:

rno:25262

Pfam:

PF08709

Uniprot:

P29994

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序列长度:

2750

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