Itm2c (基因名), Integral membrane protein 2C (蛋白名), itm2c_rat.
通用注释
亚单元:
Interacts with BACE1. Interacts with APP. Interacts with STMN2.
功能:
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
亚细胞位置:
Lysosome membrane
Single-pass type II membrane protein
Cell membrane
Single-pass type II membrane protein
数据库链接
验证序列:
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