Rat Ist1/ IST1 homolog CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

检测方法:

CLIA

特异性:

Natural and recombinant rat IST1 homolog

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

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Rat Ist1 CLIA Kit

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通用注释

亚单元:

Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4. Interacts with SPG20 (via MIT domain); leading to the recruitment of SPG20 to midbodies. Interacts with SPAST.

功能:

ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST.

亚细胞位置:

Cytoplasmic vesicle Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Midbody Nucleus envelope Localizes to centrosome and midbody of dividing cells. Colocalized with SPG20 to the ends of Flemming bodies during cytokinesis. Localizes to the nuclear envelope during late anaphase.

数据库链接

UniGene:

Rn.2250

SMR:

Q568Z6

STRING:

10116.ENSRNOP00000020365

KEGG:

rno:307833

Pfam:

PF03398

Uniprot: