Irgm (基因名), Immunity-related GTPase family M protein (蛋白名), irgm_rat.
通用注释
亚单元:
N/A
功能:
Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility.
亚细胞位置:
Golgi apparatus membrane
Cell membrane
Cytoplasmic vesicle
Phagosome membrane
Cytoplasmic vesicle
Autophagosome membrane
Cell projection
Phagocytic cup
Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi.
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