Bovine IPO13/ Importin-13 CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

Imp13

检测方法:

CLIA

特异性:

Natural and recombinant bovine Importin-13

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

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Bovine IPO13 CLIA Kit

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通用注释

亚单元:

Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.

功能:

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.

亚细胞位置:

Cytoplasm Nucleus

数据库链接

UniGene:

Bt.7175

STRING:

9913.ENSBTAP00000025142

KEGG:

bta:523399

Pfam:

PF03810

Uniprot: