Rat Insig1/ Insulin-induced gene 1 protein CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

Immediate-early protein CL-6, Insulin-induced growth response protein CL-6, INSIG-1, Cl-6

检测方法:

CLIA

特异性:

Natural and recombinant rat Insulin-induced gene 1 protein

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

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Rat Insig1 CLIA Kit

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通用注释

亚单元:

Binds to the SCAP-SREBF2 complex only in the presence of sterols. Interacts with RNF139. Interacts with HMGCR (via its SSD); the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with AMFR/gp78 (via its membrane domain); the interaction recruits HMCR at the ER membrane for its ubiquitination and degradation by the sterol-mediated ERAD pathway.

功能:

Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.

亚细胞位置:

Endoplasmic reticulum membrane Multi-pass membrane protein

数据库链接

UniGene:

Rn.772

STRING:

10116.ENSRNOP00000009233

KEGG:

rno:64194

Pfam:

PF07281

Uniprot: