Rat Inpp4a/ Inositol polyphosphate-4-phosphatase type I A CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

Inositol polyphosphate 4-phosphatase type I, Type I inositol 3, 4-bisphosphate 4-phosphatase

检测方法:

CLIA

特异性:

Natural and recombinant rat Inositol polyphosphate-4-phosphatase type I A

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

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Rat Inpp4a CLIA Kit

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通用注释

亚单元:

Interacts with INPP5F.

功能:

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PubMed:7608176). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (PubMed:7608176). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity).

亚细胞位置:

Early endosome membrane Recycling endosome membrane Cell membrane Nucleus Cytoplasm Cell junction Synapse Postsynaptic cell membrane Postsynaptic density Translocates to the plasma membrane upon EGF stimulation (By similarity). Shuttles between the cytoplasm and the nucleus, depending on the cell cycle stage, with highest amounts detected in the nucleus during the G0/G1phase (By similarity).

数据库链接

UniGene:

Rn.11215

STRING:

10116.ENSRNOP00000024330

KEGG:

rno:80849

Uniprot:

Q62784

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