Rat Impact/ Protein IMPACT CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

Imprinted and ancient gene protein homolog

检测方法:

CLIA

特异性:

Natural and recombinant rat Protein IMPACT

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

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Rat Impact CLIA Kit

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通用注释

亚单元:

Interacts with GCN1; prevents the interaction of GCN1 with EIF2AK4/GCN2 and inhibits EIF2AK4/GCN2 kinase activity. Interaction with RPL39; this interaction occurs in a GCN1-independent manner. Associates with ribosomes; this interaction occurs in a GCN1-independent manner. Associates with actin; this interaction occurs in a GCN1-independent manner.

功能:

Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.

亚细胞位置:

Cytoplasm

数据库链接

UniGene:

Rn.190651

SMR:

Q5GFD9

STRING:

10116.ENSRNOP00000064200

KEGG:

rno:497198

Pfam: