Human KPNA2/ Importin subunit alpha-1 CLIA Kit
输入蛋白亚基-2

货号:

U1138h

商标:

EIAab^®

监管等级:

RUO

别名:

Karyopherin subunit alpha-2, RAG cohort protein 1, SRP1-alpha, RCH1, SRP1

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant human Importin subunit alpha-1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human KPNA2 CLIA Kit

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产品说明书

说明书:

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通用注释

亚单元:

Forms a complex with importin subunit beta-1. Found in a complex with CSE1L/XPO2, Ran and KPNA2. Interacts with CSE1L/XPO2 and NBN. Interacts with ANP32E (By similarity). Interacts with HIV-1 Vpr and PLAG1. Interacts with APEX1 (via N-terminus). Interacts with ARL4A; the interaction is direct.

功能:

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

亚细胞位置:

Cytoplasm Nucleus

数据库链接

Uniprot:

P52292

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