Mouse Ifitm3/ Interferon-induced transmembrane protein 3 CLIA Kit
干扰素有道跨膜蛋白3

货号:

U10026m

商标:

EIAab^®

监管等级:

RUO

别名:

Dispanin subfamily A member 2b, Fragilis protein, Interferon-inducible protein 15, Mouse ifitm-like protein 1, DSPA2b, Mil-1

检测方法:

CLIA

特异性:

Natural and recombinant mouse Interferon-induced transmembrane protein 3

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Mouse Ifitm3 CLIA Kit

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通用注释

亚单元:

Interacts with SPP1; the interaction reduces OPN expression (By similarity). Interacts with ATP6V0B and CD81.

功能:

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV) and human immunodeficiency virus type 1 (HIV-1). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. Involved in initiating germ cell competence and specification, and in the demarcation of PGCs from their somatic neighbors.

亚细胞位置:

Cell membrane Single-pass type II membrane protein Late endosome membrane Single-pass type II membrane protein Lysosome membrane Single-pass type II membrane protein

数据库链接

UniGene:

Mm.141021

STRING:

10090.ENSMUSP00000026565

KEGG:

mmu:66141

Pfam:

PF04505

Uniprot:

Q9CQW9