首页 > 化学发光试剂盒 > Mouse Ifit3 CLIA Kit

Ifit3 (基因名), Interferon-induced protein with tetratricopeptide repeats 3 (蛋白名), ifit3_mouse.

产品名称:

Mouse Ifit3/ Interferon-induced protein with tetratricopeptide repeats 3 CLIA Kit
具有四肽重复序列的干扰素诱导蛋白

货号:

U2804m

商标:

EIAab^®

监管等级:

RUO

别名:

Glucocorticoid-attenuated response gene 49 protein, IRG2, GARG-49, IFIT-3, Garg49, Ifi49, Isg49

检测方法:

CLIA

特异性:

Natural and recombinant mouse Interferon-induced protein with tetratricopeptide repeats 3

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Immunology

规格 & 价格:

关注

Mouse Ifit3 CLIA Kit

邮箱 *

消息 *

Please 登录.

产品说明书

在线询价

数据
文献
序列 / 3D
反馈墙 (0)

通用注释

亚单元:

Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT1 and IFIT2 (By similarity). Interacts (via N-terminus) with MAVS, TBK1, TRAF6 and DDX58 (By similarity). Interacts with COPS5.

功能:

IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.

亚细胞位置:

Cytoplasm Mitochondrion

数据库链接

UniGene:

Mm.426079

SMR:

Q64345

STRING:

10090.ENSMUSP00000099889

KEGG:

mmu:15959

Pfam: