Ifih1 (基因名), Interferon-induced helicase C domain-containing protein 1 (蛋白名), ifih1_mouse.
产品名称:
Mouse Ifih1/ Interferon-induced helicase C domain-containing protein 1 CLIA Kit
干扰素诱导解旋酶C域蛋白1
货号:
U2803m
商标:
EIAab®
监管等级:
别名:
Helicase with 2 CARD domains, Interferon induced with helicase C domain protein 1, Melanoma differentiation-associated protein 5, RIG-I-like receptor 2, Helicard, MDA-5, RLR-2
检测方法:
CLIA
特异性:
Natural and recombinant mouse Interferon-induced helicase C domain-containing protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Immunology
通用注释
亚单元:
Monomer in the absence of ligands and homodimerizes in the presence of dsRNA ligands. Can assemble into helical or linear polymeric filaments on long dsRNA. Interacts with MAVS/IPS1. Interacts with V protein of Sendai virus. Binding to paramyxoviruses V proteins prevents IFN-beta induction, and the further establishment of an antiviral state. Interacts with PCBP2. Interacts with NLRC5. Interacts with PIAS2-beta. Interacts with DDX60. Interacts with ANKRD17. Interacts with IKBKE. Interacts (via the CARD domains) with TKFC, the interaction is inhibited by viral infection.
功能:
Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and theiler's murine encephalomyelitis virus (TMEV). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.
亚细胞位置:
Cytoplasm
Nucleus
May be found in the nucleus, during apoptosis.
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