Bovine HPF1/ Histone PARylation factor 1 CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

检测方法:

CLIA

特异性:

Natural and recombinant bovine Histone PARylation factor 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

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Bovine HPF1 CLIA Kit

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通用注释

亚单元:

Interacts with PARP1 (via the PARP catalytic domain). Interacts with histone H2A and histone H3 in a PARP1-dependent manner. Weakly interacts with PARP2 (via the PARP catalytic domain).

功能:

Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine. Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1.

亚细胞位置:

N/A

数据库链接

UniGene:

Bt.44222

STRING:

9913.ENSBTAP00000026815

KEGG:

bta:525698

Pfam:

PF10228

Uniprot: