Pig HORMAD1/ HORMA domain-containing protein 1 CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

检测方法:

CLIA

特异性:

Natural and recombinant pig HORMA domain-containing protein 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

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Pig HORMAD1 CLIA Kit

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通用注释

亚单元:

Interacts with HORMAD2. Interacts with IHO1/CCDC36.

功能:

Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.

亚细胞位置:

Nucleus Chromosome Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity).

数据库链接

UniGene:

Ssc.27038

SMR:

E2IUK4

STRING:

9823.ENSSSCP00000007090

KEGG:

ssc:100499502

Pfam:

PF02301

Uniprot: