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HORMAD1 (基因名), HORMA domain-containing protein 1 (蛋白名), horm1_canlf.
产品名称:

Dog HORMAD1/ HORMA domain-containing protein 1 CLIA Kit

货号:
-
商标:
EIAab®
监管等级:
检测方法:
CLIA
特异性:
Natural and recombinant dog HORMA domain-containing protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Dog HORMAD1 CLIA Kit
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Dog HORMAD1 CLIA Kit
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通用注释


亚单元:
Interacts with HORMAD2. Interacts with IHO1/CCDC36.


功能:
Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.


亚细胞位置:
Nucleus Chromosome Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-378 is restricted to unsynapsed chromosomal regions (By similarity).


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