Human HNRNPK/ Heterogeneous nuclear ribonucleoprotein K CLIA Kit
异质核核糖蛋白K

货号:

U0351h

商标:

EIAab^®

监管等级:

RUO

别名:

Transformation up-regulated nuclear protein, TUNP, hnRNP K, HNRPK

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

4.69-300pg/mL

特异性:

Natural and recombinant human Heterogeneous nuclear ribonucleoprotein K

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Epigenetics

规格 & 价格:

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Human HNRNPK CLIA Kit

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产品说明书

说明书:

MSDS:

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通用注释

亚单元:

Interacts with RBM42 and ZIK1. Interacts with BRDT (By similarity). Identified in the spliceosome C complex. Interacts with ANKRD28. Interacts with HCV core protein. Interacts with ASFV p30 protein. Interacts with DDX1. Interacts with MDM2; this interaction leads to ubiquitination and proteasomal degradation. Interacts with p53/TP53.

功能:

One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.

亚细胞位置:

Cytoplasm Nucleus Nucleoplasm Cell projection Podosome Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53 (PubMed:16360036). In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear (PubMed:18775702).

数据库链接

UniGene:

Hs.522257

SMR:

P61978

STRING:

9606.ENSP00000365439

KEGG:

hsa:3190

MIM:

600712

Pfam: