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Hmgb3 (基因名), High mobility group protein B3 (蛋白名), hmgb3_mouse.
产品名称:

Mouse Hmgb3/ High mobility group protein B3 CLIA Kit
高迁移率族蛋白B3

货号:

U0257m

商标:
EIAab®
监管等级:
别名:

High mobility group protein 2a, High mobility group protein 4, HMG-2a, HMG-4, Hmg2a, Hmg4

检测方法:
CLIA
特异性:
Natural and recombinant mouse High mobility group protein B3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Hmgb3 CLIA Kit
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Mouse Hmgb3 CLIA Kit
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通用注释


亚单元:
N/A


功能:
Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (PubMed:19890330). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (PubMed:12714519, PubMed:15358624, PubMed:16945912).


亚细胞位置:
Nucleus Chromosome Cytoplasm


该产品尚未在任何出版物中被引用。
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