Mouse Hmces/ Abasic site processing protein HMCES CLIA Kit
胚胎干细胞特异性5-羟甲基胞嘧啶结合蛋白

货号:

U15335m

商标:

EIAab^®

监管等级:

RUO

别名:

Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, Peptidase HMCES, Putative endonuclease HMCES, SRAP domain-containing protein 1, ES cell-specific 5hmC-binding protein, Srap1, Srapd1

检测方法:

CLIA

特异性:

Natural and recombinant mouse Abasic site processing protein HMCES

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Mouse Hmces CLIA Kit

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通用注释

亚单元:

Interacts (via PIP-box motif) with PCNA.

功能:

Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (By similarity). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA (By similarity). The HMCES DNA-protein cross-link is then degraded by the proteasome (By similarity). Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (PubMed:29020633). Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells (PubMed:23434322). May act as an endonuclease that specifically cleaves 5hmC-containing DNA; additional experiments are however required to confirm this activity in vivo (PubMed:29020633).

亚细胞位置:

Chromosome Recruited to chromatin following DNA damage. Localizes to replication forks.

数据库链接

UniGene:

Mm.246241

SMR:

Q8R1M0

STRING:

10090.ENSMUSP00000032141

KEGG:

mmu:232210

Pfam: