Human HIF1AN/ Hypoxia-inducible factor 1-alpha inhibitor CLIA Kit
低氧诱导因子1-α抑制剂

货号:

U0495h

商标:

EIAab^®

监管等级:

RUO

别名:

Factor inhibiting HIF-1, Hypoxia-inducible factor asparagine hydroxylase, FIH-1, FIH1

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant human Hypoxia-inducible factor 1-alpha inhibitor

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human HIF1AN CLIA Kit

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产品说明书

说明书:

MSDS:

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通用注释

亚单元:

Homodimer; homodimerization is essential for catalytic activity. Interacts with VHL and HIF1A. Part of a complex with VHL, HIF1A and HDAC1 or HDAC2 or HDAC3. Interacts with NFKB1 and NFKBIA. Interacts with NOTCH1, NOTCH2 and NOTCH3 but not with NOTCH4. Interacts with APBA3; binding inhibits HIF1AN binding to HIF1A. Interacts with TNKS2. Interacts with PPP1R12A. Interacts with ASB4 (By similarity). Interacts with UBE3A. Interacts with ANKS3.

功能:

Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.

亚细胞位置:

Nucleus Cytoplasm Cytoplasm Perinuclear region Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.

数据库链接

UniGene:

Hs.500788

SMR:

Q9NWT6

STRING:

9606.ENSP00000299163

KEGG:

hsa:55662

MIM:

606615

Uniprot: