Hey2 (基因名), Hairy/enhancer-of-split related with YRPW motif protein 2 (蛋白名), hey2_mouse.
产品名称:
Mouse Hey2/ Hairy/enhancer-of-split related with YRPW motif protein 2 CLIA Kit
毛状/分裂增强子与YRPW基序蛋白相关2
货号:
U14339m
商标:
EIAab®
监管等级:
别名:
HES-related repressor protein 2, Hairy and enhancer of split-related protein 2, Hairy-related transcription factor 2, Protein gridlock homolog, HESR-2, HRT-2, Chf1, Herp, Herp1, Hesr2, Hrt2
检测方法:
CLIA
特异性:
Natural and recombinant mouse Hairy/enhancer-of-split related with YRPW motif protein 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Development Biology
通用注释
亚单元:
May self-associate (By similarity). Interacts with ARNT (By similarity). Interacts with GATA4, GATA6, HES1 and HEYL. Interacts with HDAC1, NCOR1 and SIN3A.
功能:
Transcriptional repressor which functions as a downstream effector of Notch signaling in cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY1 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3.
亚细胞位置:
Nucleus
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