Human HDAC8/ Histone deacetylase 8 CLIA Kit
组蛋白脱乙酰酶8

货号:

U1111h

商标:

EIAab^®

监管等级:

RUO

别名:

CDA07, HD8, HDACL1

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

78-5000pg/mL

特异性:

Natural and recombinant human Histone deacetylase 8

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

关注

Human HDAC8 CLIA Kit

邮箱 *

消息 *

Please 登录.

产品说明书

说明书:

MSDS:

在线询价

数据
文献
序列 / 3D
反馈墙 (0)

通用注释

亚单元:

Interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv(16)(p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate in the conversion of RUNX1 into a constitutive transcriptional repressor. Interacts with CBFA2T3. Interacts with phosphorylated SMG5/EST1B; this interaction protects SMG5 from ubiquitin-mediated degradation. Associates with alpha-SMA (smooth muscle alpha-actin).

功能:

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.

亚细胞位置:

Nucleus Cytoplasm Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.

数据库链接

UniGene:

Hs.310536

SMR:

Q9BY41

STRING:

9606.ENSP00000362674

KEGG:

hsa:55869

MIM: