Hdac6 (基因名), Histone deacetylase 6 (蛋白名), hdac6_mouse.
产品名称:
Mouse Hdac6/ Histone deacetylase 6 CLIA Kit
组蛋白脱乙酰酶6
货号:
U11377m
商标:
EIAab®
监管等级:
别名:
Histone deacetylase mHDA2, HD6
检测方法:
CLIA
特异性:
Natural and recombinant mouse Histone deacetylase 6
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Interacts with BBIP10, DDIT3/CHOP, F-actin and HDAC11. Interacts with SIRT2 (via both phosphorylated, unphosphorylated, active or inactive forms); the interaction is necessary for the complex to interact with alpha-tubulin. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions (By similarity). Interacts with CBFA2T3, CYLD and ZMYND15. Interacts with FAM65B.
功能:
In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.
亚细胞位置:
Nucleus
Cytoplasm
Perikaryon
Cell projection
Dendrite
Cell projection
Axon
It is mainly cytoplasmic, where it is associated with microtubules.
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