Human HCLS1/ Hematopoietic lineage cell-specific protein CLIA Kit

货号:

U15649h

商标:

EIAab^®

监管等级:

RUO

别名:

Hematopoietic cell-specific LYN substrate 1, LckBP1, p75, HS1

检测方法:

CLIA

特异性:

Natural and recombinant human Hematopoietic lineage cell-specific protein

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human HCLS1 CLIA Kit

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通用注释

亚单元:

Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. Interacts with FES/FPS (By similarity). Interacts (via SH2 domain) with FGR. Forms a multiprotein complex with LYN and ANKRD54.

功能:

Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.

亚细胞位置:

Membrane Peripheral membrane protein Cytoplasm Mitochondrion

数据库链接

UniGene:

Hs.14601

SMR:

P14317

STRING:

9606.ENSP00000320176

KEGG:

hsa:3059

MIM: