Mouse H2afx/ Histone H2AX CLIA Kit
组蛋白H2A.x

货号:

U15010m

商标:

EIAab^®

监管等级:

RUO

别名:

Histone H2A.X, H2a/x, H2a.x, H2ax, Hist5-2ax

检测方法:

CLIA

特异性:

Natural and recombinant mouse Histone H2AX

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Epigenetics

规格 & 价格:

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Mouse H2afx CLIA Kit

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产品说明书

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通用注释

亚单元:

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. May interact with numerous proteins required for DNA damage signaling and repair when phosphorylated on Ser-140. These include MDC1, TP53BP1 and the MRN complex, composed of MRE11, RAD50, and NBN. Interaction with the MRN complex is likely mediated at least in part by NBN. May also interact with DHX9/NDHII when phosphorylated on Ser-140 and MCPH1 when phosphorylated at Ser-140 or Tyr-143.

功能:

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

亚细胞位置:

Nucleus Chromosome

数据库链接

UniGene:

Mm.245931

SMR:

P27661

STRING:

10090.ENSMUSP00000051432

KEGG:

mmu:15270

Pfam: