Human GRB14/ Growth factor receptor-bound protein 14 CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

GRB14 adapter protein

检测方法:

CLIA

特异性:

Natural and recombinant human Growth factor receptor-bound protein 14

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

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Human GRB14 CLIA Kit

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通用注释

亚单元:

Interacts with the cytoplasmic domain of the autophosphorylated insulin receptor (INSR), through the SH2 domain (By similarity). Interacts with GRB14 (via BPS domain); this interaction protects the tyrosines in the activation loop on INSR from dephosphorylation. Binds to the ankyrin repeat region of TNKS2 via its N-terminus. Interacts with activated NRAS. Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated).

功能:

Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

亚细胞位置:

Cytoplasm Endosome membrane Peripheral membrane protein Upon insulin stimulation, translocates to the plasma membrane.

数据库链接

UniGene:

Hs.411881

SMR:

Q14449

STRING:

9606.ENSP00000263915

KEGG:

hsa:2888

MIM: