Mouse Gdf5/ Growth/differentiation factor 5 CLIA Kit
生长分化因子5

货号:

U0550m

商标:

EIAab^®

监管等级:

RUO

别名:

Bone morphogenetic protein 14, BMP-14, GDF-5, Bmp14, Bp, Gdf-5

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

3.9-250pg/mL

特异性:

Natural and recombinant mouse Growth/differentiation factor 5

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Mouse Gdf5 CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

数据
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序列 / 3D
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通用注释

亚单元:

Homodimer; disulfide-linked (By similarity). Interacts with serine proteases, HTRA1 and HTRA3 (PubMed:15206957, PubMed:14973287). Following LPS binding, may form a complex with CXCR4, HSP90AA1 and HSPA8 (By similarity). Interacts with high affinity with NOG; inhibits chondrogenesis (By similarity). Interacts with high affinity with BMPR1B and lower affinity with BMPR1A; positively regulates chondrocyte differentiation and induces SMAD-dependent signaling. Interacts with FBN1 (via N-terminal domain) and FBN2.

功能:

Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (By similarity). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (By similarity). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (PubMed:24076600). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

亚细胞位置:

Secreted Cell membrane

数据库链接

UniGene:

Mm.4744

STRING:

10090.ENSMUSP00000048079

KEGG:

mmu:14563

Pfam:

PF00019

Uniprot: