GCN1 (基因名), eIF-2-alpha kinase activator GCN1 (蛋白名), gcn1_human.
产品名称:
Human GCN1/ eIF-2-alpha kinase activator GCN1 CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
GCN1 eIF-2-alpha kinase activator homolog, GCN1-like protein 1, General control of amino-acid synthesis 1-like protein 1, Translational activator GCN1, HsGCN1, GCN1L1, KIAA0219
检测方法:
CLIA
特异性:
Natural and recombinant human eIF-2-alpha kinase activator GCN1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with EIF2AK4/GCN2; this interaction stimulates the EIF2AK4/GCN2 kinase activity and is impaired by IMPACT upon a variety of stress conditions, such as amino acid depletion, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Interacts with IMPACT; this prevents the interaction of GCN1 with EIF2AK4/GCN2 and inhibits EIF2AK4/GCN2 kinase activity.
功能:
Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.
亚细胞位置:
Cytoplasm
Associates with ribosomes in undifferentiated neuroblastoma cells and increases after neuronal differentiation.
验证序列:
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