Pig GAPDH/ Glyceraldehyde-3-phosphate dehydrogenase CLIA Kit
3-磷酸甘油醛脱氢

货号:

U1932p

商标:

EIAab^®

监管等级:

RUO

别名:

Peptidyl-cysteine S-nitrosylase GAPDH, GAPDH, GAPD

检测方法:

CLIA

特异性:

Natural and recombinant pig Glyceraldehyde-3-phosphate dehydrogenase

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Neurosciences

规格 & 价格:

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Pig GAPDH CLIA Kit

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通用注释

亚单元:

Homotetramer. Interacts with EIF1AD, USP25, PRKCI and WARS. Interacts with TPPP; the interaction is direct. Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation. Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules. Associates with microtubules. Interacts with phosphorylated RPL13A (By similarity). Component of the GAIT complex. Interacts with FKBP6; leading to inhibit GAPDH catalytic activity.

功能:

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.

亚细胞位置:

Cytoplasm Cytosol Nucleus Cytoplasm Cytoskeleton Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal.

数据库链接

UniGene:

Ssc.16135

SMR:

P00355

KEGG:

ssc:396823

Pfam:

PF02800

Uniprot:

P00355