GAPDH (基因名), Glyceraldehyde-3-phosphate dehydrogenase (蛋白名), g3p_canfa.
产品名称:
Dog GAPDH/ Glyceraldehyde-3-phosphate dehydrogenase CLIA Kit
3-磷酸甘油醛脱氢
货号:
U1932d
商标:
EIAab®
监管等级:
别名:
Peptidyl-cysteine S-nitrosylase GAPDH, GAPDH, GAPD
检测方法:
CLIA
特异性:
Natural and recombinant dog Glyceraldehyde-3-phosphate dehydrogenase
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Neurosciences
通用注释
亚单元:
Homotetramer. Interacts with EIF1AD, USP25, PRKCI and WARS. Interacts with TPPP; the interaction is direct. Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation. Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation.
功能:
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC.
亚细胞位置:
Cytoplasm
cytosol
Nucleus
Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal.
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