Ezr (基因名), Ezrin (蛋白名), ezri_rat.
产品名称:
Rat Ezr/ Ezrin CLIA Kit
Ezrin
货号:
U1297r
商标:
EIAab®
监管等级:
别名:
Cytovillin, Villin-2, p81, Vil2
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
3.9-250pg/mL
特异性:
Natural and recombinant rat Ezrin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Epigenetics
通用注释
亚单元:
Interacts with PODXL and SLC9A3R2. Found in a complex with EZR, PODXL and SLC9A3R2 (PubMed:11457882). Interacts with MPP5. Interacts with MCC, PLEKHG6, SCYL3/PACE1, SLC9A3R1 and TMEM8B. Interacts (when phosphorylated) with FES/FPS. Interacts with dimeric S100P, the interaction may be activating through unmasking of F-actin binding sites (By similarity). Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (By similarity). Detected in a complex composed of at least EZR, AHNAK, PPL and PRX.
功能:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
亚细胞位置:
Apical cell membrane
Peripheral membrane protein
Cytoplasmic side
Cell projection
Cell projection
Microvillus membrane
Peripheral membrane protein
Cytoplasmic side
Cell projection
Ruffle membrane
Peripheral membrane protein
Cytoplasmic side
Cytoplasm
Cell cortex
Cytoplasm
Cytoskeleton
Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Microvillar peripheral membrane protein (cytoplasmic side) (By similarity). Localizes to cell extensions and peripheral processes of astrocytes. Colocalizes with EZR and SLC9A3R2 at the apical cell membrane of glomerular epithelium cells.
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