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ERN1 (基因名), Serine/threonine-protein kinase/endoribonuclease IRE1 (蛋白名), ern1_human.

产品名称:

Human ERN1/ Serine/threonine-protein kinase/endoribonuclease IRE1 CLIA Kit
丝氨酸/苏氨酸-蛋白激酶/内切核糖核酸酶IRE1

货号:

U7165h

商标:

EIAab^®

监管等级:

RUO

别名:

Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, Ire1-alpha, hIRE1p, IRE1a, IRE1

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant human Serine/threonine-protein kinase/endoribonuclease IRE1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Signal Transduction

规格 & 价格:

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产品说明书

说明书:

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通用注释

亚单元:

Interacts with DAB2IP (via PH domain); the interaction occurs in a ER stress-induced dependent manner and is required for subsequent recruitment of TRAF2 to ERN1 (By similarity). Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges. Also binds HSPA5, a negative regulator of the unfolded protein response. This interaction may disrupt homodimerization and prevent activation of ERN1. Interacts with TAOK3 and TRAF2.

功能:

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

亚细胞位置:

Endoplasmic reticulum membrane Single-pass type I membrane protein

数据库链接

UniGene:

Hs.133982

SMR:

O75460

STRING:

9606.ENSP00000401445

KEGG:

hsa:2081

MIM: