ERBB2 (基因名), Receptor tyrosine-protein kinase erbB-2 (蛋白名), erbb2_canfa.
产品名称:
Dog ERBB2/ Receptor tyrosine-protein kinase erbB-2 CLIA Kit
受体酪氨酸蛋白激酶erbB-2
货号:
U1867d
商标:
EIAab®
监管等级:
别名:
Proto-oncogene c-ErbB-2, p185erbB2, CD340
检测方法:
CLIA
特异性:
Natural and recombinant dog Receptor tyrosine-protein kinase erbB-2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Homodimer. Heterodimer with ERBB3. Heterodimer with each of the other ERBB receptors (Potential). Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1200. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1252) with MEMO1. Interacts with MUC1. Interacts (when phosphorylated on Tyr-1138) with GRB7 (via SH2 domain). Interacts (when phosphorylated on Tyr-1252) with ERBB2IP. Interacts with KPNB1, RANBP2, EEA1, CRM1, CLTC, RPA94 and ACTB.
功能:
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
亚细胞位置:
Cell membrane
Single-pass type I membrane protein
Cytoplasm
perinuclear region
Nucleus
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