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Enpp1 (基因名), Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (蛋白名), enpp1_rat.

产品名称:

Rat Enpp1/ Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 CLIA Kit
外核苷酸焦磷酸酶/磷酸二酯酶家族成员1

货号:

U1032r

商标:

EIAab^®

监管等级:

RUO

别名:

Phosphodiesterase I/nucleotide pyrophosphatase 1, Plasma-cell membrane glycoprotein PC-1, E-NPP 1, Npps, Pc1, Pdnp1

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

3.9-250pg/mL

特异性:

Natural and recombinant rat Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Metabolism

规格 & 价格:

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产品说明书

说明书:

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通用注释

亚单元:

Homodimer. The secreted form is monomeric. Interacts with INSR.

功能:

By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.

亚细胞位置:

Cell membrane Single-pass type II membrane protein Basolateral cell membrane Single-pass type II membrane protein Secreted Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side. The proteolytically processed form is secreted.

数据库链接

UniGene:

Rn.1199

SMR:

Q924C3

STRING:

10116.ENSRNOP00000019519

KEGG:

rno:85496

Pfam:

PF01223

Uniprot: