EIAab
首页  >  化学发光试剂盒  >  Human EIF2AK3 CLIA Kit
EIF2AK3 (基因名), Eukaryotic translation initiation factor 2-alpha kinase 3 (蛋白名), e2ak3_human.
产品名称:

Human EIF2AK3/ Eukaryotic translation initiation factor 2-alpha kinase 3 CLIA Kit
真核翻译起始因子2-α激酶3

货号:

U11434h

商标:
EIAab®
监管等级:
别名:

PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, HsPEK, PEK, PERK

检测方法:
CLIA
实验类型:
Sandwich
检测范围:
39-2500pg/mL
特异性:
Natural and recombinant human Eukaryotic translation initiation factor 2-alpha kinase 3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Neurosciences
Human EIF2AK3 CLIA Kit
规格 & 价格: cart
×
Human EIF2AK3 CLIA Kit
邮箱 *
消息 *
Please 登录.
产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3 and MFN2 (By similarity). Interacts with TMEM33 (PubMed:26268696).


功能:
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.


亚细胞位置:
Endoplasmic reticulum membrane Single-pass type I membrane protein


该产品尚未在任何出版物中被引用。
关闭
Sample Data
关闭
Sample Data
关闭
Sample Data
用户中心 close
购物车 close
我的收藏 close
我的足迹 close
清除
产品对比 close
用户中心
购物车
我的收藏
我的足迹
产品对比
回到顶部
通知
new 咨询
规格 数量 单价 (¥) 小计 1 (¥)
小计 2:
triangle
规格 数量 单价 (¥)
你想做我们的代理并得到更低的折扣吗?
请联系我们:
电话:027-59234612(+86)
传真:027-59234610(+86)
邮箱:sales@eiaab.com