EIF2AK3 (基因名), Eukaryotic translation initiation factor 2-alpha kinase 3 (蛋白名), e2ak3_human.
产品名称:
Human EIF2AK3/ Eukaryotic translation initiation factor 2-alpha kinase 3 CLIA Kit
真核翻译起始因子2-α激酶3
货号:
U11434h
商标:
EIAab®
监管等级:
别名:
PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, HsPEK, PEK, PERK
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
39-2500pg/mL
特异性:
Natural and recombinant human Eukaryotic translation initiation factor 2-alpha kinase 3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Neurosciences
通用注释
亚单元:
Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3 and MFN2 (By similarity). Interacts with TMEM33 (PubMed:26268696).
功能:
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
亚细胞位置:
Endoplasmic reticulum membrane
Single-pass type I membrane protein
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