DTD2 (基因名), D-aminoacyl-tRNA deacylase 2 (蛋白名), dtd2_chick.
产品名称:
Chicken DTD2/ D-aminoacyl-tRNA deacylase 2 CLIA Kit
货号:
U16083c
商标:
EIAab®
监管等级:
别名:
Animalia-specific tRNA deacylase, D-tyrosyl-tRNA(Tyr) deacylase 2, L-alanyl-tRNA deacylase, ATD
检测方法:
CLIA
特异性:
Natural and recombinant chicken D-aminoacyl-tRNA deacylase 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
-
通用注释
亚单元:
Homodimer.
功能:
Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (By similarity). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (By similarity). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. In contrast to DTD1, deacylates L-Ala mischarged on tRNA(Thr)(G4.U69) by alanine-tRNA ligase AARS (PubMed:29410408). Can deacylate L-Ala due to a relaxed specificity for substrate chirality caused by the trans conformation of the Gly-Pro motif in the active site (PubMed:29410408). Also hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) in vitro, although in vivo EEF1A1/EF-Tu may protect cognate achiral glycyl-tRNA(Gly) from DTD2-mediated deacetylation (By similarity).
亚细胞位置:
Cytoplasm
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