Bovine IQCG/ Dynein regulatory complex protein 9 CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

IQ domain-containing protein G, DRC9

检测方法:

CLIA

特异性:

Natural and recombinant bovine Dynein regulatory complex protein 9

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

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Bovine IQCG CLIA Kit

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通用注释

亚单元:

Component of the nexin-dynein regulatory complex (N-DRC). Interacts (via IQ domain) with CALM when calcium levels are low. Does not interact with CALM in the presence of Ca(2+). Interacts with the HSP70 proteins HSPA1L and HSPA8. May form a complex with CAMK4 and HSP70.

功能:

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility.

亚细胞位置:

Cytoplasm Cell projection Cilium Flagellum Cell projection Cilium Cytoplasm Cytoskeleton Cytoplasm Cytoskeleton Flagellum axoneme First detected in the cytoplasm of pachytene spermatocytes. Colocalizes with alpha-tubulin at the manchette in developing spermatids. Detected in the flagellum of mature testicular spermatozoa, and in the flagellum and post-acrosomal region of the head of epididymal spermatozoa. Detected in cilia in trachea and oviduct.

数据库链接

UniGene:

Bt.56204

SMR:

Q2T9V2

STRING:

9913.ENSBTAP00000023995

KEGG:

bta:613455

Pfam:

PF00612

Uniprot: