Mouse Ddr2/ Discoidin domain-containing receptor 2 CLIA Kit
盘状蛋白结构域受体2

货号:

U1505m

商标:

EIAab^®

监管等级:

RUO

别名:

CD167 antigen-like family member B, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO10, CD167b, Discoidin domain receptor 2, Ntrkr3, Tkt, Tyro10

检测方法:

CLIA

特异性:

Natural and recombinant mouse Discoidin domain-containing receptor 2

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Mouse Ddr2 CLIA Kit

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通用注释

亚单元:

Binds hydroxyproline-rich sequence motifs in fibrillar, glycosylated collagen, such as the GQOGVMGFO motif, where O stands for hydroxyproline. Interacts with SRC. Interacts (tyrosine phosphorylated) with SHC1.

功能:

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

亚细胞位置:

Cell membrane Single-pass type I membrane protein

数据库链接

UniGene:

Mm.229249

SMR:

Q62371

STRING:

10090.ENSMUSP00000027985

KEGG:

mmu:18214

Pfam: