Mouse Ddr1/ Epithelial discoidin domain-containing receptor 1 CLIA Kit
上皮细胞盘状结构域受体1

货号:

U15103m

商标:

EIAab^®

监管等级:

RUO

别名:

CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, Protein-tyrosine kinase MPK-6, Tyrosine kinase DDR, Tyrosine-protein kinase CAK, CD167a, Epithelial discoidin domain receptor 1, Cak, Eddr1, Mpk6

检测方法:

CLIA

实验类型:

Sandwich

特异性:

Natural and recombinant mouse Epithelial discoidin domain-containing receptor 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Mouse Ddr1 CLIA Kit

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产品说明书

说明书:

MSDS:

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通用注释

亚单元:

Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2.

功能:

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (By similarity). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing.

亚细胞位置:

Cell membrane Single-pass type I membrane protein

数据库链接

UniGene:

Mm.5021

SMR:

Q03146

STRING:

10090.ENSMUSP00000003628

KEGG:

mmu:12305

Pfam: