Rat Dapk3/ Death-associated protein kinase 3 CLIA Kit
死亡相关蛋白激酶3

货号:

U15322r

商标:

EIAab^®

监管等级:

RUO

别名:

DAP-like kinase, MYPT1 kinase, ZIP-kinase, Dlk, DAP kinase 3, Zipk

检测方法:

CLIA

特异性:

Natural and recombinant rat Death-associated protein kinase 3

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Rat Dapk3 CLIA Kit

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通用注释

亚单元:

Homooligomer in its kinase-active form (homotrimers and homodimers are reported); monomeric in its kinase-inactive form. Homodimerization is required for activation segment autophosphorylation (By similarity). Interacts with DAXX, ATF4, NLK, TCF7L2, UBE2D1, UBE2D2, UBE2D3 and CDC5L. Interacts with PAWR; also demonstrated in aorta smooth muscle cells indicative for the cytoskeletal targeting function of PAWR. Interacts with AR; enhanced by AATF.

功能:

Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in formation of promyelocytic leukemia protein nuclear body (PML-NB). Involved in apoptosis involving PAWR which mediates cytoplasmic relocation; in vitro phosphorylates PAWR. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton such as in regulation of cell polarity and cell migration. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2; disrupts the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition (By similarity). Phosphorylates STAT3 and enhances its transcriptional activity (By similarity). Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis.

亚细胞位置:

Nucleus Nucleus PML body Cytoplasm Cytoplasm Cytoskeleton Microtubule organizing center Chromosome Centromere Cytoplasm Cytoskeleton Predominantly localized to the nucleus. Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments (Probable). Associated with the centrosomes throughout the mitotic cell cycle, with the centromeres from prophase to anaphase and with the contractile ring during cytokinesis.

数据库链接

UniGene:

Rn.60353

SMR:

O88764

STRING:

10116.ENSRNOP00000027634

KEGG:

rno:64391

Pfam:

PF00069

Uniprot: