Cxcr4 (基因名), C-X-C chemokine receptor type 4 (蛋白名), cxcr4_mouse.
产品名称:
Mouse Cxcr4/ C-X-C chemokine receptor type 4 CLIA Kit
CXC趋化因子受体4
货号:
U2170m
商标:
EIAab®
监管等级:
别名:
Fusin, Leukocyte-derived seven transmembrane domain receptor, Pre-B-cell-derived chemokine receptor, Stromal cell-derived factor 1 receptor, LESTR, PB-CKR, SDF-1 receptor, CD184, CXC-R4, Cmkar4, Lestr, Sdf1r
检测方法:
CLIA
特异性:
Natural and recombinant mouse C-X-C chemokine receptor type 4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
Neurosciences
通用注释
亚单元:
Monomer (By similarity). Can form dimers (By similarity). Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin; the interaction enhances intracellular calcium ions and reduces cellular cAMP levels (By similarity). Interacts with CD164. Interacts with DBN1; this interaction is enhanced by antigenic stimulation (By similarity). Following LPS binding, may form a complex with GDF5, HSP90AA1 and HSPA8.
功能:
Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.
亚细胞位置:
Cell membrane
Multi-pass membrane protein
Cell junction
Early endosome
Late endosome
Lysosome
In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated (By similarity). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC) (By similarity).
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