Rat Crhr1/ Corticotropin-releasing factor receptor 1 CLIA Kit
促肾上腺皮质激素释放因子受体1

货号:

U1168r

商标:

EIAab^®

监管等级:

RUO

别名:

Corticotropin-releasing hormone receptor 1, CRH-R-1, CRF-R-1, Crhr

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant rat Corticotropin-releasing factor receptor 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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产品说明书

说明书:

MSDS:

在线询价

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通用注释

亚单元:

Interacts (via N-terminal extracellular domain) with CRH and UCN. Interacts with DLG1; this inhibits endocytosis of CRHR1 after agonist binding (By similarity). Heterodimer; heterodimerizes with GPER1.

功能:

G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

亚细胞位置:

Cell membrane Multi-pass membrane protein Endosome Agonist-binding promotes endocytosis.

数据库链接

UniGene:

Rn.10499

SMR:

P35353

STRING:

10116.ENSRNOP00000006764

KEGG:

rno:58959

Pfam: