Human CRBN/ Protein cereblon CLIA Kit
小脑蛋白

货号:

U12793h

商标:

EIAab^®

监管等级:

RUO

别名:

AD-006

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

39-2500pg/mL

特异性:

Natural and recombinant human Protein cereblon

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human CRBN CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

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通用注释

亚单元:

Interacts with KCNT1 (By similarity). Component of a DCX (DDB1-CUL4-X-box) protein ligase complex, at least composed of CRBN, CUL4A, DDB1 and RBX1. Interacts directly with DDB1 (PubMed:25043012, PubMed:25108355). Interacts (in pomalidomide-bound form) with IKZF1 and IKZF3 (PubMed:24328678).

功能:

Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.

亚细胞位置:

Cytoplasm Nucleus Membrane Peripheral membrane protein

数据库链接

UniGene:

Hs.18925

SMR:

Q96SW2

STRING:

9606.ENSP00000231948

KEGG:

hsa:51185

MIM: