C9 (基因名), Complement component C9 (蛋白名), co9_bovin.
通用注释
亚单元:
Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. About 20 C9 chains oligomerize to give rise to a huge beta-barrel that forms a 100 Angstrom diameter pore in target mebranes.
功能:
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
亚细胞位置:
Secreted
Target cell membrane
Multi-pass membrane protein
Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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