C5 (基因名), Complement C5 (蛋白名), co5_human.
产品名称:
Human C5/ Complement C5 CLIA Kit
补体C5
货号:
U1969h
商标:
EIAab®
监管等级:
别名:
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, CPAMD4
检测方法:
CLIA
特异性:
Natural and recombinant human Complement C5
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Neurosciences
通用注释
亚单元:
C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). The C5a anaphylatoxin interacts with C5AR1. Interacts with tick complement inhibitor.
功能:
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
亚细胞位置:
Secreted
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