Cntn1 (基因名), Contactin-1 (蛋白名), cntn1_rat.
通用注释
亚单元:
Monomer (By similarity). Interacts with NOTCH1 (By similarity). Interacts with CNTNAP1 in cis form and TNR (PubMed:9118959, PubMed:9081628). Binds to the carbonic-anhydrase like domain of PTPRZ1 (PubMed:7628014). Detected in a complex with NRCAM and PTPRB.
功能:
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
亚细胞位置:
Cell membrane
Lipid-anchor
GPI-anchor
数据库链接
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