Hspe1 (基因名), 10 kDa heat shock protein, mitochondrial (蛋白名), ch10_rat.
产品名称:
Rat Hspe1/ 10 kDa heat shock protein, mitochondrial CLIA Kit
热休克蛋白10
货号:
U1501r
商标:
EIAab®
监管等级:
别名:
10 kDa chaperonin, Chaperonin 10, CPN10, Hsp10
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
0.125-8ng/mL
特异性:
Natural and recombinant rat 10 kDa heat shock protein, mitochondrial
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
Epigenetics
通用注释
亚单元:
Homoheptamer arranged in a ring structure. 2 heptameric Hsp10 rings interact with a Hsp60 tetradecamer in the structure of a back-to-back double heptameric ring to form the symmetrical football complex.
功能:
Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein.
亚细胞位置:
Mitochondrion matrix
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